Statistics of Primera División Uruguaya in season 1928.
It was contested by 16 teams, and Peñarol won the championship.
| Pos | Club | P | W | D | L | GF | GA | Pts |
| 1 | Peñarol | 30 | 20 | 5 | 5 | 66 | 22 | 45 |
| 2 | Rampla Juniors | 30 | 15 | 7 | 8 | 44 | 24 | 37 |
| 3 | Nacional | 30 | 12 | 11 | 7 | 40 | 26 | 35 |
| 4 | Cerro | 30 | 11 | 12 | 7 | 32 | 33 | 34 |
| 5 | Sud América | 30 | 11 | 11 | 8 | 28 | 21 | 33 |
| 6 | Defensor | 30 | 12 | 8 | 10 | 36 | 32 | 32 |
| 7 | Capurro | 30 | 11 | 10 | 9 | 30 | 33 | 32 |
| 8 | Misiones | 30 | 11 | 9 | 10 | 36 | 35 | 31 |
| 9 | Bella Vista | 30 | 11 | 8 | 11 | 35 | 34 | 30 |
| 10 | Colón | 30 | 10 | 9 | 11 | 33 | 43 | 29 |
| 11 | Montevideo Wanderers | 30 | 9 | 10 | 11 | 25 | 29 | 28 |
| 12 | Olimpia | 30 | 9 | 10 | 11 | 31 | 44 | 28 |
| 13 | Liverpool | 30 | 8 | 10 | 12 | 30 | 34 | 26 |
| 14 | Uruguay | 30 | 7 | 7 | 16 | 31 | 53 | 21 |
| 15 | Racing Montevideo | 30 | 7 | 6 | 17 | 33 | 49 | 20 |
| 16 | Lito | 30 | 5 | 9 | 16 | 32 | 50 | 19 |
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